Enforcing the law within the notoriously rough Brownsville section of the city and especially within the Van Dyke housing projects is the NYPD's sixty-fifth precinct. Three police officers struggle with the sometimes fine line between right and wrong.
Seen-it-all New York detective Frank Keller is unsettled - he has done twenty years on the force and could retire, and he hasn't come to terms with his wife leaving him for a colleague. Joining up with an officer from another part of town to investigate a series of murders linked by the lonely hearts columns he finds he is getting seriously and possibly dangerously involved with Helen, one of the main suspects.
When 4 year old Amanda McCready disappears from her home and the police make little headway in solving the case, the girl's aunt, Beatrice McCready hires two private detectives, Patrick Kenzie and Angie Gennaro. The detectives freely admit that they have little experience with this type of case, but the family wants them for two reasons - they're not cops and they know the tough neighborhood in which they all live. As the case progresses, Kenzie and Gennaro face drug dealers, gangs and pedophiles. When they are about to solve the case, they are faced with a moral dilemma that tears them apart.
Special Agent Jennifer Marsh (Diane Lane) works in an elite division of the FBI dedicated to fighting cybercrime. She thinks she has seen it all, until a particularly sadistic criminal arises on the Internet. This tech-savvy killer posts live feeds of his crimes on his website; the more hits the site gets, the faster the victim dies. Marsh and her team must find the elusive killer before time runs out.
Tom Ludlow is a disillusioned L.A. Police Officer, rarely playing by the rules and haunted by the death of his wife. When evidence implicates him in the execution of a fellow officer, he is forced to go up against the cop culture he's been a part of his entire career, ultimately leading him to question the loyalties of everyone around him.
There is something horribly wrong with the bodies found in the dark city streets. Some are mutilated while others have the Price equation (wΔz = Cov (w,z) = βwzVz) carved into their flesh. Detective Eddie Argo and his new partner Helen Westcott unearth the meaning of the odd equation and realise each victim is being offered a gruesome choice: kill your loved ones, or be killed. Before long it becomes clear that the perpetrator has suffered a similar fate and is now coping by seeking a way to solve this philosophical dilemma.
When a madman dubbed 'Scorpio' terrorizes San Francisco, hard-nosed cop, Harry Callahan – famous for his take-no-prisoners approach to law enforcement – is tasked with hunting down the psychopath. Harry eventually collars Scorpio in the process of rescuing a kidnap victim, only to see him walk on technicalities. Now, the maverick detective is determined to nail the maniac himself.
Homicide detective John Hobbes witnesses the execution of serial killer Edgar Reese. Soon after the execution the killings start again, and they are very similar to Reese's style.